Projects: ME/CFS Research Program

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Expansion of LIINC collaborative study to ME/CFS

Project Summary: To use advanced technologies to study critically important – yet understudied – biological factors in ME/CFS patients whose illness...

Lumbrokinase LongCOVID & ME/CFS clinical trial

Project Summary:A clinical trial to test if the fibrinolytic enzyme Lumbrokinase improves symptoms and mitigates blood clotting issues or platelet hyperactivation in...

Impact of tick-borne/vector-borne infection on post-COVID symptoms

Project summary:A project performed in concert with the Steve & Alexandra Cohen Foundation to determine the degree to which patients with...

Delineation of coagulation, innate immune, and vascular blood-based biomarkers in infection-associated chronic disease

Project Summary:A project is using advanced microscopy and microfluidic assays to identify & quantify 1) fibrinaloid microclots 2) activated platelets 3)...

Optimizing fluorescence microscopy as a high throughput method for detecting biofilm in fibrinaloid microclots

Project summary: A study employing advanced fluorescence microscopy to determine if fibrinaliod microclots isolated from Long COVID and ME/CFS blood contain bacterial...

Immune activity, viral activity, and microclotting in Long COVID and ME/CFS peripheral neuropathy

Project Summary:A project to determine if pathogen persistence, immune dysregulation, and blood vessel dysfunction or microclotting contribute to small fiber neuropathy...

Neuroinflammation and “brain fog” in Long COVID & ME/CFS

Project summary: A project to determine the extent to which glial activation (part of neuroinflammation) is contributing to ‘brain fog’ cognitive dysfunction...

Deep profiling of pathogen antibody reactivities, immune factors, and autoantibodies in ME/CFS blood & cerebrospinal fluid

Project summary:To use high-throughput approaches to characterize 1) pathogen antibody reactivites 2) immune and endocrine markers 3) autoantobodies in both blood...

Ultrahigh resolution 7-Tesla imaging of structural abnormalities, cerebrospinal fluid flow, and other symptom mechanisms in patients with infection-associated chronic disease

Project summary:A carefully conceptualized series of MRI brain scans using ultrahigh resolution 7-Tesla imaging in patients with infection-associated chronic disease (eg:...

A Tissue Analysis Pipeline to analyze samples collected from patients with infection-associated chronic disease

Project Summary:A multi-method collaborative research study supported by the Steve & Alexandra Cohen Foundation and PolyBio, conceptualized by PolyBio scientists. The...

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