Current Projects

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Identification of immune and protein biomarkers in NeuroLongCOVID cerebrospinal fluid

Project Summary: A project using advanced technologies such as transcriptomics and integrated single-cell sequencing to investigate if altered immune activation or...

Support of the Long-term Impact of Infection with Novel Coronavirus (LIINC) program: A Clinical Core to facilitate Long COVID collaborative research

Project Summary: To support the ongoing Long-term Impact of Infection with Novel Coronavirus (LIINC) cohort study, so that it can serve...

A multi-inflammatory “hit” model of LongCOVID, plus the impact of SARS-CoV-2 protein on vagus nerve signaling

Project Summary: A project to study whether “multiple hits” (e.g., different viral or bacterial infections) increase the risk of chronic symptom...

Immune activity and microclotting in Long COVID peripheral neuropathy

Project Summary: A project to determine if immune dysregulation, blood vessel dysfunction and/or microclotting contribute to small fiber neuropathy in patients...

Optimizing fluorescence microscopy as a high throughput method for detecting biofilm in fibrinaloid microclots

Project summary:  A study employing advanced fluorescence microscopy to determine if fibrinaliod microclots isolated from Long COVID and ME/CFS blood contain...

Investigating the role of SARS-CoV-2 persistence in the gastrointestinal tract in Long COVID

Project Summary: This collaborative study uses advanced complementary methods to determine if SARS-CoV-2 or its proteins can persist for long periods...

Innate neuroimmunity and cognitive function in Long COVID

Project summary:  A project to determine the extent to which glial activation (part of neuroinflammation) is contributing to ‘brain fog’ cognitive...

Deep profiling of pathogen antibody reactivities, immune factors, and autoantibodies in ME/CFS blood & cerebrospinal fluid

Project summary: To use high-throughput approaches to characterize 1) pathogen antibody reactivites 2) immune and endocrine markers 3) autoantobodies in both...

Ultrahigh resolution 7-Tesla imaging of structural abnormalities, cerebrospinal fluid flow, and other symptom mechanisms in patients with infection-associated chronic disease

Project summary: A carefully conceptualized series of MRI brain scans using ultrahigh resolution 7-Tesla imaging in patients with infection-associated chronic disease...

A Tissue Analysis Pipeline to analyze samples collected from patients with infection-associated chronic disease

Project Summary: A multi-method collaborative research study supported by the Steve & Alexandra Cohen Foundation and conceptualized in concert with...