Current Projects

Lumbrokinase LongCOVID & ME/CFS clinical trial

Project Summary: A clinical trial to test if the fibrinolytic enzyme Lumbrokinase improves symptoms and mitigates blood clotting issues or platelet hyperactivation...

Long COVID oral cavity biomarker study

Project summary: To determine the degree to which the oral cavity can serve as a window into the identification LongCOVID immune,...

Mechanistic biomarker discovery of LongCOVID endotypes

Project Summary: To identify LongCOVID endotypes (groups of patients with common symptoms) via a combination of computational modeling and machine learning...

LongCOVID open medical education program

Project summary: Development of a comprehensive education program on LongCOVID and related virus-driven chronic illness. Educational materials will be offered online free...

LongCOVID clinic clean indoor air initiative

Project Summary: A collaboration with the OSLUV Project to improve the air quality of the Cohen Center for Recovery from Complex...

Long COVID: Using SARS-CoV-2 specific CD8 T cells as biosensors of viral persistence

Project Summary: This project will determine if CD8 T cells specific for SARS-CoV-2 proteins can be used as blood-based biosensors of...

Use of total-body PET imaging to identify deep-tissue SARS-CoV-2 viral reservoirs and T cell responses in patients with Long COVID

Project Summary:  This study is the first in the world to use advanced imaging technologies to identify deep tissue SARS-CoV-2 reservoirs...

LongCovid: Developing antivirals to treat persistent infection

Project summary:  This study will directly inform how therapeutics can best be positioned into clinical trials aimed at clearing potential SARS-CoV-2...

Evaluation of tissue fibrin accumulation and perfusion in Long COVID, via Fibrin-PET imaging & peripheral blood analysis

Project Summary: The project is the first in the world to use advanced positron emission tomography (PET) imaging to test the...

Decoding lymphoid tissue adaptive immune responses connected with Long COVID

Project Summary: This study will determine if Long COVID is connected to altered immune responses in lymphoid tissue. The project team...

SARS-CoV-2 gut persistence, intestinal permeability, and spike protein in pediatric Long COVID & MIS-C

Project Summary: This study is testing the hypothesis that Long COVID in children is associated with chronic reservoirs of SARS-CoV-2 in...

Delineation of coagulation, innate immune, and vascular blood-based biomarkers in infection-associated chronic disease

Project Summary: A project is using advanced microscopy and microfluidic assays to identify & quantify 1) fibrinaloid microclots 2) activated platelets...