Current Projects

Evidence of SARS-CoV-2 RNA persistence from ongoing stimulation of virus-specific B cell responses in Long COVID

Project Summary: A study to determine if immune cells in Long COVID blood are responding to proteins created by the SARS-CoV-2...

Elucidation of SARS-CoV-2 reservoir and related LongCovid pathology in lung tissue, fluid, and blood using molecular virology & advanced sequencing

Project Summary: A multi-site collaborative study to identify infectious, immune and microbiome abnormalities that contribute to pulmonary symptoms in individuals with...

Analysis of Long COVID microclots for pathogens and their proteins

Project Summary: A collaborative study to investigate the degree to which viral proteins or bacterial products contribute to the composition of...

Advanced sequencing to determine potential viral, immune and genetic drivers of endometriosis

Project summary: A collaborative project to determine if infection (including that driven by the SARS-CoV-2 virus) and the accompanying host immune...

Probing the role of endogenous and latent viruses in Long COVID

Project Summary: This study is probing the relationship among human endogenous retrovirus (HERV) activity, viral and bacterial pathogen reactivation, the human...

Identification of immune and protein biomarkers in NeuroLongCOVID cerebrospinal fluid

Project Summary: A project using advanced technologies such as transcriptomics and integrated single-cell sequencing to investigate if altered immune activation or...

Support of the Long-term Impact of Infection with Novel Coronavirus (LIINC) program: A Clinical Core to facilitate Long COVID collaborative research

Project Summary: To support the ongoing Long-term Impact of Infection with Novel Coronavirus (LIINC) cohort study, so that it can serve...

A multi-inflammatory “hit” model of LongCOVID, plus the impact of SARS-CoV-2 protein on vagus nerve signaling

Project Summary: A project to determine if “multiple hits” (e.g., different viral or bacterial infections) increase the risk of chronic symptom...

Optimizing fluorescence microscopy as a high throughput method for detecting biofilm in fibrinaloid microclots

Project summary:  A study employing advanced fluorescence microscopy to determine if fibrinaliod microclots isolated from Long COVID and ME/CFS blood contain...

Immune activity and microclotting in Long COVID and ME/CFS peripheral neuropathy

Project Summary: A project to determine if immune dysregulation, blood vessel dysfunction or microclotting contribute to small fiber neuropathy in patients...

Investigating the role of SARS-CoV-2 persistence in the gastrointestinal tract in Long COVID

Project Summary: This collaborative study uses advanced complementary methods to determine if SARS-CoV-2 or its proteins can persist for long periods...

Innate neuroimmunity and cognitive function in Long COVID & ME/CFS

Project summary:  A project to determine the extent to which glial activation (part of neuroinflammation) is contributing to ‘brain fog’ cognitive...